A novel protecting strategy for internucleosidic phosphate and phosphorothioate groups.
نویسندگان
چکیده
The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.
منابع مشابه
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ورودعنوان ژورنال:
- Nucleosides, nucleotides & nucleic acids
دوره 20 4-7 شماره
صفحات -
تاریخ انتشار 2001